Women with a gene that causes breast cancer are building a illness roughly 8 years progressing than their mothers or aunts who also had a disease, a new examine suggests.
The findings, published Sept. 12 in Cancer, a peer-reviewed biography of a American Cancer Society, could change a approach women are screened for breast cancer in a future, a study?s authors say.
?There is a trend altogether that a age of conflict for breast cancer is removing younger,? pronounced Banu Arun, comparison author of a study.
Researchers from a MD Anderson Cancer Center during a University of Texas followed 132 women who tested certain for possibly a BRCA 1 or BRCA 2 gene, and found 106 had a womanlike family member in a prior era with possibly breast or ovarian cancer.
Women can be tested for a BRCA genes, famous as swelling suppressors, mutations of that have been related to a significantly increasing patrimonial risk of building breast and ovarian cancer.
In comparing a women?s ages during diagnosis, researchers found a daughters were diagnosed roughly 8 years progressing than women in a prior generation.
Arun, a medical oncologist and professor, pronounced she was not astounded to see a study?s findings.
?We have somehow seen that trend that with any successive era we are saying younger conflict of breast cancer,? Arun said.
The study?s authors trust a trend could be explained by a materialisation famous as anticipation.
Anticipation occurs in genetic diseases such as Huntington?s, in that a illness occurs during younger ages or with increasing astringency from era to era as a outcome of a DNA instability.
The commentary showed a median age of diagnosis was 42 for a second era compared with a median age of 48 in a initial generation. Using a mathematical indication to comment for anticipation, a researchers found a normal disproportion in age of breast cancer conflict between generations was 7.9 years.
However, Arun pronounced a commentary exhibit there might be a multiple of factors concerned in a progressing onset, including hormones, diet, lifestyle and environmental factors, that a examine did not investigate.
Steven Narod, co-discoverer of a BRCA 1 and BRCA 2 gene, claimed there are several flaws in a investigate that impact a study?s conclusion. One problem, he said, is a researchers insincere a mothers and aunts of women who tested certain for a BRCA genetic turn carried a same mutation.
With a view to possible 1500000000 $ per year in tax revenue the state of California will vote this fall on the legalization of marijuana, a step, a step toward recognizing the invalidity of legislative behavior that is not enforceable.
The founder of Facebook has donated $ 100,000 to help the measure pass.
The religious right is to see this as further support of decadence. All over the world, religion has long been used to try to control people. Legalization of MarijuanaThey weaken significantly to controlling it.
You see the same phenomenon in the Islamic world, where sex is the big problem. The editor of Indonesian Playboy was arrested in Bali last week, sought by the Islamic authorities to serve two years in prison for publishing indencency. The magazine was closed in 2006 after the release of only a few problems.
An Islamic extremists in Indonesia Arnadi Erwin as a "terrorist morale." What I can not see is thatYou can not control people's behavior, let alone her thoughts.
Daily in Tehran, Iran, the Islamists by sending vehicles specifically for women who are not dressed according to code, for women, which can be upgraded, or for situations in which an unmarried man and a woman alone.
What all of these thought police can not seem to get that people are going to do these things anyway, so the application is an endless task.
Religion has always managedControl human behavior for a long time. And that's a good thing.
The reason for this is that it is good to have a spiritual life has nothing compelled by an external body is doing.
Spirituality is something that absolutely must come from the individual.
Through our religious-based morality, we as a species have withered the spiritual quest for the transformation of the finite to the infinite for the possession by a series of moral laws to live. This is a serious distortionwhat the spiritual journey is everything.
They do not apply to anyone who has the Ten Commandments have failed a hopeless answer? They were ignored in any case. The whole thrust of the Hebrew Scriptures is that you can not succeed with a moral standard. That is why an alliance was necessary, one on the heart.
As St. Paul said in an intuitive long ago in a letter to the people of Rome, a society that was obsessed with the rule of law, but all the waydecadent, trying to boost morale with laws actually make things worse.
All of humanity is in a state of arrested spiritual development, because our understanding of how humans are moral agents have returned. Do the sane thing is, in our being, the one with the divine, is not to be incurred in the rules of society.
Catholic author Sebastian Moore says: "In the spiritual life, insights, the only motivation and inertia-shifting;the only people who sustained us in our comfort zone and then touch the difference in our lives, are the ones that come from our own discoveries. "
All the way up to 2000-3000 years have seen a handful of insightful people, that only if the integrity of the heart comes from a level that we can live a lifetime and are integrated.
Divine love is an internal impulse, not something to be applied.
When people quit smoking marijuana, mustcome from a personal awareness. It is likely to dawn on them how they deal with their emotional pain and integrate this pain.
Spirituality is an inside job, an affair of the heart. When erect the Ten Commandments could not imagine a nation we can be our crusade against marijuana never really go to work.
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MOSCOW ? All three engines on a Russian jet that slammed into a riverbank were operating up until the moment of the crash and the plane's stabilizer and flaps were in a proper position for takeoff, Russian experts said Friday.
Still, the Moscow-based Interstate Aviation Committee, which is conducting the crash probe, had no conclusions yet about the cause of the crash that killed 43 people, mostly members of a top Russian ice hockey team.
The comments came as aviation experts examined flight data recorders from the crashed plane and began safety checks Friday on Yak-42 jets nationwide.
The chartered Yak-42 jet crashed Wednesday into the sides of the Volga River on a sunny, clear day moments after taking off near Yaroslavl, a city 150 miles (240 kilometers) northeast of Moscow.
It was one of the worst aviation disasters ever in sports, shocking Russia and the world of hockey, for among the dead were 36 players, coaches and staff of the Lokomotiv Yaroslavl hockey team. The team had been heading to Minsk, Belarus, to play its opening game of the Kontinental Hockey League season.
Two men survived the crash ? player Alexander Galimov and crew member Alexander Sizov ? but they were in critical condition Friday, both in medicated comas after being transferred to Moscow for treatment. Hospital officials said Galimov had burns over 90 percent of his body.
The Interstate Aviation Committee said magnetic tapes holding the flight information in the data recorders were wet, but its experts have begun deciphering those segments that have dried out, learning about the engines. The committee didn't specify, however, whether the engines were giving the full thrust.
The Tunoshna airport's runway was three times longer than required for that type of plane but the plane had still failed to accelerate sufficiently before takeoff, Russian Deputy Transport Minister Valery Okulov said.
Authorities were also checking fuel supplies at the Tunoshna airport, suspecting that low quality fuel could have caused the crash. The airport has been allowed to resume operations but planes were barred from using local fuel.
Yaroslavl Gov. Sergei Vakhrukov, however, insisted that the fuel couldn't have been the cause, since another plane using the same fuel had flown without any problems.
The crashed jet was built in 1993 and one of its three engines was replaced a month ago, transportation officials said.
Aviation authorities also were running safety checks on all the approximately 60 Yak-42 jets currently in service in Russia, which was expected to lead to disruptions in service. An Associated Press reporter was among the passengers ordered to disembark Friday from a Yak-42 jet bound on an internal flight from Moscow.
In Yaroslavl, where there has been an outpouring of public grief over the deaths of the hockey players, a memorial service was to be held Saturday at the team's arena. Several squads from the Kontinental Hockey League were traveling to Yaroslavl to take part.
Thousands of fans have already come to the Yaroslavl arena to pay their respects, laying mounds of red roses and carnations outside its walls.
President Dmitry Medvedev has called for sweeping reforms to Russia's aviation industry, including replacing aging Russian jets with Western planes.
Experts blame Russia's poor aviation safety record on an aging fleet, weak government controls, poor pilot training and a cost-cutting mentality.
___
Lynn Berry in Yaroslavl, Russia, and Natalia Vasilyeva in Moscow contributed to this report.
1 Successful Internet Marketing Business Opportunity Idea ? Free Training Available
Are you looking for a successful internet marketing business idea? Well, truth is that if you do not take the initiative to learn how a successful business idea works and what it takes to be successful in that business, then you are not really looking for a successful business idea.
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Shut your eyes! Think about a well-appointed, spacious, air conditioned and luxurious limousine. For a number of years, a limousine has been the chosen style of transport for business and leisure travellers. A limo will turn any journey into an exciting adventure. Why a limousine makes travel so surprising is that the automobile has been built to meet the needs of its passengers. Wherever you are travelling to or why you?re travelling you?ll find that a limousine is the only possible way to travel.
If you?re planning a holiday, instead of making an attempt to arrange transport, why not hire a limo for the duration of your holiday? Hiring a limousine will give you the chance to travel in total style. Think how special you?ll feel when you arrive at the air terminal and a classy limo is waiting to transport you to your hotel! If you?d like to see the awesome sights and attractions of the town, once again, a limo is the ideal method of transport. You will feel extra-special as you are transported about the city?s streets while you take great pleasure in all the comforts offered by a limo. If you are travelling on business, limo hire Brisbane can meet all your travelling needs.
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There are a number of limo hire firms who will eagerly customise their services to meet the wants of their clientele. As well as hiring a limo for a holiday, many select this extra-special style of transport for a marriage rite, a girl?s night out or a bachelor or bachelorette party. With limo hire, the need to navigate about busy town streets is eliminated and the passengers onboard the limousine can utilize the travel time to chill, complete work or simply enjoy the pleasures available.
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Cellular metabolism self-adapts to protect against free radicalsPublic release date: 7-Sep-2011 [ | E-mail | Share ]
Contact: Dr. Patricia Marquardt patricia.marquardt@molgen.mpg.de 49-308-413-1716 Max-Planck-Gesellschaft
Feedback mechanism coordinates cellular respiration and the degradation of free oxygen radicals
This press release is available in German.
Oxygen-consuming organisms obtain energy through cellular respiration, which is the transformation of carbohydrates and oxygen into carbon dioxide and water. This process also produces toxic oxygen radicals which must be decomposed immediately, as they would otherwise cause damage to cells. Scientists from the Max Planck Institute for Molecular Genetics in Berlin have now discovered a mechanism, with whose help cells can coordinate respiratory activity and the degradation of free radicals. Thus, the cells prepare their metabolism for free radicals before they even arise.
Cellular respiration is a very efficient process through which a lot of energy is generated from a few sugar molecules and oxygen. However, up to two percent of the oxygen used in this process is transformed into superoxide, a free radical that is toxic to cells. A considerable proportion of this superoxide evades the respiratory chain of the mitochondria and poses a threat to biological macromolecules like DNA, RNA, proteins and fatty acids. However, evolution has equipped eukaryotic cells with comprehensive mechanisms that can decompose free radicals which arise in the cell and therefore prevent damage to the cell. These mechanisms work extremely efficiently and are well coordinated so that, contrary to popular belief, the treatment of healthy tissue with natural or synthetic antioxidants can disrupt the natural balance and, at worst, damage cells and accelerate the aging process.
Researchers at the Max Planck Institute for Molecular Genetics compared respiring and non-respiring yeast cells. When respiration was activated, there was a direct increase in the cells' tolerance to oxidised substances; however, contrary to expectation, this was not accompanied by a rise in the concentration of free radicals. This proved that respiring cells are entirely capable of dealing with the increased formation of free radicals and keeping them at the level of the non-respiring cells.
According to the researchers, a hitherto undiscovered feedback mechanism located within a central metabolic pathway is responsible for this process. The carbohydrate-degrading enzyme pyruvate kinase regulates the respiratory activity of yeast cells. It is less active in respiring cells and this leads to the accumulation of its substrate phosphoenolpyruvate. The accumulation of this substance inhibits another glycolytic enzyme, triosephosphate isomerase. The researchers were already very familiar with this enzyme: they had previously discovered that a low level of activity of this enzyme provides protection against free radicals. "If we block this feedback mechanism artificially while activating respiration, the free radical concentration increased significantly and damaged proteins and mitochondria. This tells us that cells can predict when the radical production will rise and adapt their metabolism before the free radicals are even produced," explains Markus Ralser, researcher at the Max Planck Institute for Molecular Genetics and the University of Cambridge.
This discovery may prove to be of particular significance for cancer research. The enzyme pyruvate kinase is partly responsible for the fact that tumour cells usually respire less and thus have a higher rate of sugar metabolism than healthy tissue. This effect is named after Otto Warburg, who was the first scientist to demonstrate this higher rate of sugar metabolism in cancer cells in the 1920s. The Max Planck researchers hope that it will be possible to use this newly discovered feedback mechanism to cause targeted nutrition deficiency in tumour cells and render them more vulnerable in this way.
###
Original publication:
Nana-Maria Grning, Mark Rinnerthaler, Katharina Bluemlein, Michael Mlleder, Mirjam MC Wamelink, Hans Lehrach, Cornelis Jakobs, Michael Breitenbach and Markus Ralser
Pyruvate kinase triggers a metabolic feedback loop that controls redox
metabolism in respiring cells
Cell Metabolism, September 7, 2011
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Cellular metabolism self-adapts to protect against free radicalsPublic release date: 7-Sep-2011 [ | E-mail | Share ]
Contact: Dr. Patricia Marquardt patricia.marquardt@molgen.mpg.de 49-308-413-1716 Max-Planck-Gesellschaft
Feedback mechanism coordinates cellular respiration and the degradation of free oxygen radicals
This press release is available in German.
Oxygen-consuming organisms obtain energy through cellular respiration, which is the transformation of carbohydrates and oxygen into carbon dioxide and water. This process also produces toxic oxygen radicals which must be decomposed immediately, as they would otherwise cause damage to cells. Scientists from the Max Planck Institute for Molecular Genetics in Berlin have now discovered a mechanism, with whose help cells can coordinate respiratory activity and the degradation of free radicals. Thus, the cells prepare their metabolism for free radicals before they even arise.
Cellular respiration is a very efficient process through which a lot of energy is generated from a few sugar molecules and oxygen. However, up to two percent of the oxygen used in this process is transformed into superoxide, a free radical that is toxic to cells. A considerable proportion of this superoxide evades the respiratory chain of the mitochondria and poses a threat to biological macromolecules like DNA, RNA, proteins and fatty acids. However, evolution has equipped eukaryotic cells with comprehensive mechanisms that can decompose free radicals which arise in the cell and therefore prevent damage to the cell. These mechanisms work extremely efficiently and are well coordinated so that, contrary to popular belief, the treatment of healthy tissue with natural or synthetic antioxidants can disrupt the natural balance and, at worst, damage cells and accelerate the aging process.
Researchers at the Max Planck Institute for Molecular Genetics compared respiring and non-respiring yeast cells. When respiration was activated, there was a direct increase in the cells' tolerance to oxidised substances; however, contrary to expectation, this was not accompanied by a rise in the concentration of free radicals. This proved that respiring cells are entirely capable of dealing with the increased formation of free radicals and keeping them at the level of the non-respiring cells.
According to the researchers, a hitherto undiscovered feedback mechanism located within a central metabolic pathway is responsible for this process. The carbohydrate-degrading enzyme pyruvate kinase regulates the respiratory activity of yeast cells. It is less active in respiring cells and this leads to the accumulation of its substrate phosphoenolpyruvate. The accumulation of this substance inhibits another glycolytic enzyme, triosephosphate isomerase. The researchers were already very familiar with this enzyme: they had previously discovered that a low level of activity of this enzyme provides protection against free radicals. "If we block this feedback mechanism artificially while activating respiration, the free radical concentration increased significantly and damaged proteins and mitochondria. This tells us that cells can predict when the radical production will rise and adapt their metabolism before the free radicals are even produced," explains Markus Ralser, researcher at the Max Planck Institute for Molecular Genetics and the University of Cambridge.
This discovery may prove to be of particular significance for cancer research. The enzyme pyruvate kinase is partly responsible for the fact that tumour cells usually respire less and thus have a higher rate of sugar metabolism than healthy tissue. This effect is named after Otto Warburg, who was the first scientist to demonstrate this higher rate of sugar metabolism in cancer cells in the 1920s. The Max Planck researchers hope that it will be possible to use this newly discovered feedback mechanism to cause targeted nutrition deficiency in tumour cells and render them more vulnerable in this way.
###
Original publication:
Nana-Maria Grning, Mark Rinnerthaler, Katharina Bluemlein, Michael Mlleder, Mirjam MC Wamelink, Hans Lehrach, Cornelis Jakobs, Michael Breitenbach and Markus Ralser
Pyruvate kinase triggers a metabolic feedback loop that controls redox
metabolism in respiring cells
Cell Metabolism, September 7, 2011
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Some travel insurance companies, riding on the reputation was founded a year ago, less competitive market, realized that they need to run or die, opening the world market increased by a few large, international agreements for the discerning travelers, and more important to shop around and do your own comparison.
As more and more insurance companies travel niche is born. Nobody likes to be taken for a ride, especially when they spend their hard earned money so that they are protected when they travel. Insurance companies may promise you the world, but the proof is the pudding or in this case coverage. When it comes to the safety of your family and make your travel plans are carried out smoothly, comparative is a proven way to find the protection is needed.
Travel insurance comparison is a good way to find out more may already be interested in, and to obtain more detailed information on travel insurance, that you think can offer you the coverage you need. No matter how positive you think you already own decision about who you should purchase, everyone could benefit by comparison. Here are some reasons why.
When you visit an insurance broker, they will ask tough questions. On the other hand will increase the awareness of you, that you do not know half as much that you thought you did. When these hard questions are asked, you can honestly say that insurance is not important?
Important questions, such as an insurance professional liability insurance, travel, and more you can afford not to know enough?
It is important to be sure, when you?re on the road. Of course, 99 times out of 100, you do not need it at all, but if something bad happens to you a distant land, you will never be happy.
Travel insurance is insurance that covers medical expenses and financial issues (such as money invested in refundable advance payments) and other losses on voyages, either at home or abroad. This insurance can usually be temporarily held in reserve to cover the journey in exactly the duration of the trip, or greater, continuous insurance can be purchased from travel agents or directly from suppliers such as cruise ships or travel tour operators.
Please visit http://www.unchartedventures.com/travel-insurance-comparison/ for more guides and information.
Aurelia is a jet-setter. She always has this childish dreams to tour around the world because she loves to travel. But at this moment shes is an insurer of a company in the united States. She writes stuff all about travel insurance comparison and publish reviews about it online.
This entry was posted
on Tuesday, September 6th, 2011 at 3:58 pm and is filed under travel insurance.
You can follow any responses to this entry through the RSS 2.0 feed.
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This is the definitive textbook on strategic planning and management in healthcare organizations for those pursuing a career in health care in undergraduate, business, and medical schools, as well as ancillary health professions such as nursing or physician assistant. Established health care professionals, including doctors who are completing programs in business administration, will also find this text to be extremely valuable in preparation for greater involvement in the management of healthcare delivery. The book features all the basic information on strategic planning and management within the unique context of organizations concerned with the delivery and financing of health care. It does this by noting the singular strategic environment in health care, explaining the special procedures and options available to health care organizations, and providing real-life examples in the form of case studies. It includes not only a description of the basic multi-step process of creating and then managing a strategic plan, but also a detailed look at the role played by the key business functions (finance, marketing, human resources, information technology, and law) as well as specific strategic options (merger/acquisition, reorganization, joint venture) and some of the popular tools for analyzing strategic situations (balanced scorecard, Six Sigma, SWOT).
Learners should necessarily know the different kinds of terms which are in use so that a better understanding of the various concepts in "International Finance" can be arrived at. The following are the illustrative examples of some terms used in regard to the various issues and dimensions in international economics and financial functioning of multinational firm:
Direct Investments: This refers to real investments in factories, capital goods, land and inventories in foreign country where both capital and management are involved and the investor retains direct control over the use of invested capital
International economics: International economics deals with the theory of trade, the theory of commercial policy or protectionism, foreign exchange markets, balance of payments and the adjustments in balance of payments
International finance: This refers to the macro aspects of international economics such as balance of payments and the adjustment policies
Portfolio Investments: This refers to purely financial assets such as bonds and stocks denominated in foreign currency
Conglomerate:? It is multiform organization dealing in different activities and different markets
Cost of capital: It stands for the weighted average of the cost of debt and equity
Defensive Investment: It is designed to checkmate the moves of composing firm or country (at a distance)
Direct Investment: It implies capital plus technology plus management
Golden hand shake: This implies (liberal) lumpsum payment in view of voluntary (premature) retirement of an employee, represents the origin of a multinational enterprise
Host country: This represents the presence of a multinational enterprise beyond the home country
Intellectual Property Rights: (IPRs) are in the nature of patents and copy rights
International Corporation: This has a fairly representative presence in the whole world
Mergers: It means merging of two units in the same organization or different organizations merging together to form a single organization.
Multi domestic enterprise: It takes equal cognizance of multinational and domestic interests
Multinational enterprise: It has its substantial presence in more than two countries
Pyramiding: It aims at controlling a large number of subsidiaries through the holding company device
Take-over: It implies that one form has acquired control over another firm
Think global and act local: It implies that a multinational enterprise, while taking decisions in a worldwide perspective, operates on the basis of local situation
Transfer pricing: It implies the techniques of charging for goods and services transferred from one undertaking to another undertaking within the same group
Transnational Corporation: It has a substantial presence beyond the home country
Trickling down investment: It is a situation where a country, having an inflow of investment from some country (countries), has smaller outflow of investment toward some other country (countries)
Xenophobia: It is a strong dislike or distrust of foreigners
You are here: Home / News / Raytheon Combines Security Solutions and Civil Communications Businesses to Focus on Public Safety
Posted by Tim Watson on September 6, 2011 ? Leave a Comment?
Raytheon Co.?s (NYSE: RTN) network-centric systems business?has combined its security solutions and civil communications units as part of a new product line focused on public safety market opportunities.
The company said its new security and transportation systems product line will increase its cross-selling capabilities to government customers and enhance its ability to develop new technologies.
Two-decade Raytheon?transportation?systems, air traffic management and technology development veteran Michael Prout will lead the product line.
STS will provide security solutions, with an emphasis on critical infrastructure and border protection.
It will also produce interoperable communications networks and first responder equipment.
The line will also include Raytheon?s air traffic management business, which the company said helps control more than 60 percent of global airspace.
?We see increased opportunities to serve the public safety market more effectively through this new alignment,? said Network Centric Systems President Daniel Crowley.?The change further reinforces our commitment to being a leader in public safety. We have discriminating capabilities in sensing, communications, and command and control, plus the system integration skills to bring these capabilities together in a wide array of applications.?
Question by amby007: nri services in gurgaon? hi, i am an NRI looking for property management service in gurgaon, pls suggest
Best answer:
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To succeed as a personal trainer with a thriving business and plenty of return customers, you not only have to play the part, you have to look the part. This means that if you?re going to teach people how to be fit, you have to look fit. You don?t have to be Ms. Body Beautiful, but you must give off the impression that you lead a healthy lifestyle. Look fabulously fit so you exude credibility and confidence. So rule # 1: shape up first!
Becoming a Personal Trainer: Factors to Consider If you want to become a personal trainer and set up your own business, here are factors to consider:
1. Do you have the personality and patience for hand-holding people who are easily discouraged and de-motivated? An effective personal trainer needs to be a nurturing and caring fitness coach. The idea is to consistently encourage and enforce a positive attitude. You must guide them in their weight goals so that they don?t have unrealistic expectations.
2. Sign up with a personal trainer and see how he or she trains. In fact, if you can afford it, sign up with several trainers and pick up on their good qualities/techniques. Alternatively, you can do a tour of four or five gyms in your area and observe how trainers conduct their sessions. You may also ask the gym manager what his criteria are for hiring personal trainers.
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3. Get certified as a personal trainer ? most fitness clubs don?t hire non-certified personal trainers. Personal trainers need to know about kinesiology, physical fitness, sports medicine and the muscular-skeletal system. This doesn?t mean you need degrees in each, but your certification classes will teach you a little bit of everything. Also, if you can specialize, the better your chances are for your business to reach more clients. Specializing means going beyond physical fitness training; you may want to learn how to conduct rehabilitation exercises for people who had accidents or for people with chronic pain.
4. As for logistics, you need to look into: whether your business is a partnership or single proprietorship, getting a business permit and deciding if you?ll set it up from home or rent a location. You need to get personal liability insurance and learn marketing.
5. Target market ? opportunities for personal trainers are abundant, even in tough economic times. Health is an ongoing concern, no matter what one?s financial health is. Decide if you want to target your community, the corporate world, spa resorts, or people needing physical rehabilitation. You can also target government clients or private clinics, hospitals and sports medicine establishments.
6. Define your marketing strategies ? you need to market yourself effectively and this involves marketing your services at minimum cost. Decide if you want to send direct mail, post flyers in your neighborhood supermarket, library and sports arenas or make cold calls. You can also create a web site or have brochures printed and leave them at corporate offices ? if you want to service this particular niche.
7. Establish a word-of-mouth referral system ? let?s face it. People would be a little hesitant to run their fingers through the yellow pages. Word-of-mouth recommendations are as important as marketing yourself. Let others do the marketing for you by providing excellent, courteous and knowledgeable service. Stay on top of the latest training methods and have testimonials ready in case potential clients ask to see them.
8. Volunteer ? a great way to establish a network of contacts is to volunteer time and effort in community activities. For example, if there?s a fund- raising campaign to buy new sports equipment, offer your services to campaign organizers by saying you?ll give free 10-minute demonstrations or do a free three-minute massage for donors! This is a great way to hand out your business card.
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[unable to retrieve full-text content]Are you a writer who has attempted and attempted and attempted again to get your book printed? If you have got and if you have only been met up with refusal.
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Public release date: 7-Sep-2011
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